TACC1

TACC1, also known as Transforming acidic coiled-coil containing protein 1, is a protein encoded by the TACC1 gene in humans. This gene is located on chromosome 4. TACC1 plays a crucial role in cell division and is involved in the regulation of microtubule dynamics. Specifically, it is a component of the mitotic spindle, which is essential for the proper segregation of chromosomes during mitosis.

The TACC1 protein interacts with other proteins, including tubulin, the building block of microtubules, and aurora A kinase, a key regulator of mitosis. These interactions are important for the formation and stabilization of the spindle apparatus. Dysregulation of TACC1 has been linked to various cancers, where it can contribute to genomic instability and promote uncontrolled cell proliferation. Research is ongoing to understand its precise mechanisms of action and its potential as a therapeutic target in oncology. Its involvement in cell cycle control suggests it is a critical protein for maintaining cellular homeostasis.