Substitutiematrices
Substitutiematrices, also known as substitution matrices, are tools used in bioinformatics and computational biology to score alignments between sequences, such as proteins or nucleotides. These matrices provide values indicating the likelihood or evolutionary plausibility of one amino acid or nucleotide being substituted for another over time.
In the context of protein sequence alignment, substitution matrices like the PAM (Point Accepted Mutations) and
Substitutiematrices assign scores to pairs of residues, where positive scores indicate favorable or common substitutions, and
The choice of an appropriate substitution matrix is critical in sequence alignment algorithms such as BLAST
Overall, substitutiematrices serve as fundamental components in comparative sequence analysis, aiding researchers in understanding evolutionary relationships,