StrukturenAktivitätBeurteilungen
StrukturenAktivitätBeurteilungen, often abbreviated as SAR (Structure-Activity Relationship) assessments, are a fundamental concept in medicinal chemistry and drug discovery. They involve systematically studying how the chemical structure of a molecule relates to its biological activity. This process aims to identify key structural features that are responsible for a compound's desired pharmacological effect and to understand how modifications to these features influence potency, efficacy, and selectivity.
The core principle of SAR is that changes in a molecule's structure, such as the addition or
SAR studies often begin with a "hit" compound identified through screening. This initial molecule is then systematically