Separams

Separams are a type of pharmaceutical excipient used in drug formulation. They are typically inert substances that play a crucial role in the manufacturing process of solid dosage forms, such as tablets and capsules. Their primary function is to facilitate the smooth flow of powders and granules during tablet compression or capsule filling. This flowability is essential for ensuring consistent dosing and preventing manufacturing issues like sticking or bridging in the machinery.

The composition of separams can vary, but they often consist of finely divided particles that create a lubricating effect. Common examples include magnesium stearate, stearic acid, and talc. These materials reduce friction between powder particles and between the powder and the surfaces of the manufacturing equipment. By minimizing adhesion and improving the ability of the formulation to move uniformly through the process, separams contribute to the overall efficiency and reliability of drug production. The choice of a specific param depends on factors such as the active pharmaceutical ingredient, the desired dosage form, and regulatory requirements. Their use is carefully controlled to ensure they do not negatively impact the drug's stability, dissolution, or bioavailability.