Sec7family
Sec7family refers to a group of guanine nucleotide exchange factors (GEFs) that play crucial roles in regulating small GTPases of the ADP-ribosylation factor (ARF) family. These proteins are essential components of intracellular trafficking pathways, influencing the formation and scission of transport vesicles. Sec7family GEFs catalyze the exchange of GDP for GTP on ARFs, thereby activating these GTPases and promoting downstream signaling events.
Members of the Sec7family are characterized by a conserved Sec7 domain, which is the catalytic core responsible
These GEFs are involved in a wide range of cellular processes, including the organization of the Golgi