Sec24p
Sec24p is a crucial protein component of the Saccharomyces cerevisiae SEC24 gene product. It functions as a subunit of the coat protein complex II (COPII) machinery, which is responsible for the formation of transport vesicles that bud from the endoplasmic reticulum (ER). Sec24p is specifically involved in the cargo recognition and selection process, ensuring that correctly folded proteins and other essential molecules are packaged into COPII vesicles for transport to the Golgi apparatus and beyond.
The Sec24p protein contains a pleckstrin homology (PH) domain and a beta-sheet-rich domain. These structural features
There are multiple paralogs of Sec24p in higher eukaryotes, suggesting an evolutionarily conserved role in ER-to-Golgi