Sec13p

Sec13p is a protein subunit of the.coatomer complex, a large molecular complex involved in protein transport between different cellular compartments, particularly between the endoplasmic reticulum and the Golgi apparatus. In yeast cells, specifically Saccharomyces cerevisiae, Sec13p is one of eight protein components that form the coatomer complex. Along with Sec31p, Sec22p, Sec23p, Sec24p, Sec25p, Sec16p, and Sec27p, Sec13p is essential for the proper functioning of the coatomer complex.

Sec13p has been shown to be involved in several cellular processes, including protein transport, vesicle formation, and cell signaling pathways. The coatomer complex, which contains Sec13p, is a key player in the vesicular transport process, where newly synthesized proteins and lipids are moved from one cellular compartment to another. Sec13p has been found to interact with several other proteins and lipids, suggesting its role in organizing and stabilizing the coatomer complex on vesicles.

Mutations in the SEC13 gene in yeast cells have been shown to result in temperature-sensitive growth defects, indicating that Sec13p is essential for yeast cell survival at elevated temperatures. Cells with mutated SEC13p have been found to have defects in protein secretion, suggesting a critical role for Sec13p in the coatomer complex and vesicular transport.

Overall, Sec13p plays a crucial role in maintaining cellular homeostasis through its involvement in the coatomer complex and its subsequent role in vesicular transport and protein secretion.