SUCLA2containing

SUCLA2containing refers to the presence of the SUCLA2 gene or its encoded protein within a biological context. The SUCLA2 gene, also known as succinyl-CoA ligase ADP-forming subunit alpha, is a key component of the citric acid cycle, also known as the Krebs cycle or TCA cycle. This metabolic pathway is central to cellular respiration, generating energy in the form of ATP. Specifically, SUCLA2 encodes a subunit of the succinyl-CoA synthetase enzyme, which catalyzes the reversible conversion of succinyl-CoA to succinate, producing GTP (which can be readily converted to ATP) in the process.

Variations or mutations in the SUCLA2 gene can lead to certain medical conditions. For instance, biallelic mutations in SUCLA2 have been associated with a rare mitochondrial disorder characterized by progressive external ophthalmoplegia and leukoencephalopathy. This condition highlights the critical role of functional SUCLA2 in mitochondrial energy production and neuronal health. Research into SUCLA2containing elements is important for understanding fundamental metabolic processes and for diagnosing and potentially treating related genetic disorders. The study of SUCLA2 is thus relevant to fields such as genetics, molecular biology, and clinical medicine.