SLC5A3

SLC5A3, also known as the sodium-dependent glucose transporter 3, is a protein encoded by the SLC5A3 gene in humans. This gene is part of the solute carrier family 5, which are responsible for transporting various molecules across cell membranes. SLC5A3 is a sodium-coupled glucose transporter, meaning it utilizes the electrochemical gradient of sodium ions to facilitate the uptake of glucose into cells. While initially identified as a glucose transporter, research has shown that SLC5A3 has a lower affinity for glucose compared to other transporters like SGLT1 (SLC5A1) and SGLT2 (SLC5A2). Its primary role and substrate specificity are still areas of ongoing investigation. SLC5A3 is expressed in various tissues, including the brain, kidney, and pancreas, suggesting diverse physiological functions. Mutations in the SLC5A3 gene have been linked to certain genetic disorders, although these associations are less common than those with other SGLT family members. Further research is needed to fully elucidate the precise physiological roles and clinical implications of SLC5A3.