SLC18A3

SLC18A3, also known as solute carrier family 18 member A3, is a protein encoded by the SLC18A3 gene in humans. This gene is located on chromosome 10. The protein it encodes is a vesicular transporter that plays a crucial role in the transport of monoamines across vesicular membranes. Specifically, SLC18A3 is responsible for the uptake of neurotransmitters like dopamine, norepinephrine, and serotonin into synaptic vesicles. This process is essential for the storage and subsequent release of these neurotransmitters into the synaptic cleft, which is critical for neuronal communication.

The function of SLC18A3 is vital for maintaining proper neurotransmission in the central nervous system. Dysregulation of this transporter has been implicated in various neurological and psychiatric disorders, including Parkinson's disease, depression, and schizophrenia. Research into SLC18A3 has provided insights into the mechanisms underlying these conditions and has also identified it as a potential therapeutic target. Understanding the precise molecular mechanisms of SLC18A3 and its interactions with other proteins involved in neurotransmitter metabolism continues to be an active area of scientific investigation.