SIRPalpha
SIRPalpha, also known as CD72, is a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family of proteins. It is a type I transmembrane protein that functions as a receptor for sialic acid, a carbohydrate component found on the surface of many cells. SIRPalpha is primarily expressed on the surface of natural killer (NK) cells, where it plays a crucial role in immune regulation.
The primary function of SIRPalpha is to inhibit the activation of NK cells. It achieves this by
SIRPalpha is encoded by the SIGLEC7 gene, which is located on chromosome 19 in humans. It is
SIRPalpha has been the subject of extensive research due to its potential as a therapeutic target in