SHPTP1

SHPTP1, also known as protein tyrosine phosphatase non-receptor type 15, is a protein encoded by the PTPN15 gene in humans. This protein is a member of the protein tyrosine phosphatase (PTP) family, which are enzymes that play crucial roles in cellular signaling by catalyzing the dephosphorylation of tyrosine residues on proteins. SHPTP1 specifically dephosphorylates various substrate proteins involved in pathways regulating cell growth, differentiation, and survival.

The PTPN15 gene is located on chromosome 17 in humans. SHPTP1 is expressed in a wide range of tissues, with particularly high levels observed in the brain and lymphoid tissues. Its activity is tightly regulated, and dysregulation of SHPTP1 has been implicated in several diseases, including certain types of cancer and autoimmune disorders. Research into SHPTP1 continues to uncover its diverse functions and its potential as a therapeutic target.