SH2domainmediated
SH2 domain-mediated refers to a fundamental molecular mechanism in cell signaling. SH2 domains are specialized protein modules that recognize and bind to specific phosphorylated tyrosine residues on other proteins. This binding event is crucial for the assembly of signaling complexes and the transmission of signals within the cell. When a tyrosine residue on a protein becomes phosphorylated, often by a kinase in response to an external stimulus, it creates a docking site for proteins containing SH2 domains.
The SH2 domain's ability to bind to phosphotyrosine is highly specific, with different SH2 domains recognizing