SF3B6

SF3B6, also known as SAP155, is a protein that in humans is encoded by the SF3B6 gene. This gene is located on chromosome 17 and is part of the spliceosome, a complex responsible for RNA splicing. The protein encoded by SF3B6 is a subunit of the U2 auxiliary factor (U2AF) complex, which is crucial for the recognition of the 3' splice site during pre-mRNA splicing.

The SF3B6 protein is involved in the recognition of the branch point sequence and the polypyrimidine tract upstream of the 3' splice site. It interacts with other spliceosomal components to facilitate the assembly of the spliceosome and the subsequent removal of introns from pre-mRNA. Dysregulation of SF3B6 has been implicated in various diseases, including certain types of cancer, where aberrant splicing events can lead to the production of non-functional or oncogenic proteins. Research is ongoing to understand the precise roles of SF3B6 in normal cellular processes and its contribution to disease pathogenesis. Its essential function in splicing makes it a potential target for therapeutic interventions.