SERCApumppujen
SERCA pumps, also known as Sarco/Endoplasmic Reticulum Calcium ATPases, are a family of integral membrane proteins that play a crucial role in calcium homeostasis within cells. These pumps are responsible for actively transporting calcium ions (Ca2+) from the cytoplasm into the lumen of the sarcoplasmic reticulum (SR) in muscle cells and the endoplasmic reticulum (ER) in non-muscle cells. This process is energy-dependent, utilizing the hydrolysis of adenosine triphosphate (ATP) to drive the conformational changes required for calcium transport.
The SERCA pump is a member of the P-type ATPase superfamily, characterized by its ability to undergo
The precise regulation of intracellular calcium concentration by SERCA pumps is vital for a wide range of