SEMA7As

SEMA7A, also known as Semaphorin 7A or CD108, is a transmembrane glycoprotein belonging to the semaphorin family of proteins. These proteins are known for their roles in cell signaling and are involved in various biological processes, including neuronal development, immune cell guidance, and angiogenesis. SEMA7A is characterized by its extracellular semaphorin domain, a transmembrane domain, and a short intracellular tail.

This protein is expressed on a variety of cell types, including neurons, immune cells such as T cells and macrophages, and endothelial cells. Its expression pattern suggests diverse functions. SEMA7A has been implicated in modulating immune responses, influencing cell adhesion, and promoting cell migration. It can interact with specific receptors on target cells, such as plexins and integrins, to mediate its signaling effects.

In the immune system, SEMA7A has been shown to play a role in the development and function of T cells, potentially affecting their activation and proliferation. It can also influence the behavior of other immune cells involved in inflammation and tissue repair. Beyond immunity, SEMA7A has been observed to promote neurite outgrowth in developing neurons and contributes to the formation of new blood vessels, a process known as angiogenesis. Research into SEMA7A continues to uncover its multifaceted contributions to cellular communication and tissue development.