SDO1s

SDO1s, also known as SDO-1s or SDO/NPC-1L1, refers to the sterol-25-hydroxylase domain containing 1 protein. This protein is a member of the sterol hydroxylase family and plays a crucial role in cholesterol metabolism. Specifically, SDO1 is involved in the synthesis of 25-hydroxycholesterol, a oxysterol that acts as a signaling molecule. This oxysterol can influence various cellular processes, including gene expression related to cholesterol homeostasis and inflammatory responses.

The SDO1 gene is found in humans and other vertebrates. Its expression levels can be regulated by factors involved in cholesterol uptake and synthesis. SDO1's enzymatic activity is essential for producing 25-hydroxycholesterol, which in turn interacts with other cellular components to modulate cholesterol transport and metabolism. Aberrant SDO1 function or expression has been implicated in certain metabolic disorders, highlighting its importance in maintaining cellular and organismal health. Research continues to explore the precise mechanisms by which SDO1 and its product, 25-hydroxycholesterol, contribute to diverse physiological and pathological processes.