SCL5A12

SCL5A12, also known as solute carrier family 5 member 12, is a gene that encodes a protein involved in the transport of ions and molecules across cell membranes. This protein functions as a sodium-dependent bicarbonate transporter. It plays a crucial role in maintaining pH homeostasis in various tissues.

The SCL5A12 transporter is found in several organs, including the kidney, stomach, and brain. In the kidney, it contributes to bicarbonate reabsorption in the renal tubules, which is essential for regulating blood pH and electrolyte balance. In the stomach, it is thought to be involved in acid secretion. Its presence in the brain suggests a role in neuronal function and pH regulation within the central nervous system.

Mutations in the SCL5A12 gene have been associated with certain medical conditions. For example, disruptions in its function can lead to renal tubular acidosis, a disorder characterized by impaired kidney function in excreting acid, leading to metabolic acidosis. Research into SCL5A12 continues to explore its precise physiological roles and the implications of its dysfunction in various disease states. Understanding the SCL5A12 transporter is important for comprehending cellular pH regulation and its impact on overall health.