RhDnegativen

RhDnegative refers to a blood type classification system that indicates the absence of the RhD antigen on the surface of red blood cells. This antigen is a protein that plays a role in determining an individual's blood group. When the RhD antigen is present, the blood type is considered RhDpositive. Approximately 15% of people in the United States are RhDnegative, though this percentage can vary among different ethnic groups.

The RhDnegative status is inherited from parents. An individual inherits one RhD gene from each parent. If both parents pass on a gene for the absence of the RhD antigen, the child will be RhDnegative. Conversely, if at least one parent passes on a gene for the presence of the RhD antigen, the child will be RhDpositive.

The primary clinical significance of RhDnegative blood lies in pregnancy and blood transfusions. In pregnant individuals who are RhDnegative, exposure to RhDpositive fetal blood cells can trigger the production of antibodies against the RhD antigen. This can lead to Rh disease, a serious condition that can affect future pregnancies by causing hemolytic disease of the newborn. To prevent this, RhDnegative pregnant individuals are often given Rho(D) immune globulin injections.

For blood transfusions, compatibility is crucial. RhDnegative individuals can receive RhDpositive blood, but it is generally preferred that they receive RhDnegative blood to avoid sensitization to the RhD antigen. However, RhDpositive individuals can receive both RhDpositive and RhDnegative blood. Accurate blood typing is therefore essential for safe medical procedures.