Rag1Rag2knockouthiiriä

Rag1Rag2knockouthiiriä refers to laboratory mice that have had both the Rag1 and Rag2 genes knocked out. The Rag1 and Rag2 genes are essential for V(D)J recombination, a process that occurs in developing lymphocytes (T cells and B cells) to generate the diversity of antigen receptors. V(D)J recombination is crucial for the adaptive immune system's ability to recognize and respond to a vast array of foreign pathogens.

In Rag1Rag2knockouthiiriä, the absence of functional Rag1 and Rag2 proteins prevents V(D)J recombination from occurring. Consequently, these mice are severely immunodeficient. They lack mature B cells and T cells, meaning they cannot produce functional antibodies or mount T cell-mediated immune responses. This profound lack of adaptive immunity makes them highly susceptible to infections.

These knockout mice are valuable tools in immunological research. They serve as a model system to study the development and function of the innate immune system in the absence of adaptive immunity. Researchers use Rag1Rag2knockouthiiriä to investigate the roles of innate immune cells, such as macrophages and natural killer cells, in host defense against various pathogens. They are also used to study the development of cancer, particularly lymphomagenesis, and to test the efficacy of novel therapies for immune disorders or infectious diseases. The generation and use of these mice are conducted under strict ethical guidelines for animal research.