RabGDIs
RabGDIs are a family of guanine nucleotide dissociation inhibitors that play a crucial role in regulating the activity of Rab GTPases. Rab GTPases are small molecular switches that are involved in a wide array of cellular processes, including membrane trafficking, vesicle transport, and cell division. RabGDIs bind to inactive Rab proteins, which are bound to GDP, and prevent them from associating with cellular membranes. This binding also shields the hydrophobic prenyl groups of the Rab proteins, keeping them soluble in the cytosol.
When a Rab protein needs to be activated, it is recruited to a specific cellular membrane by
The interplay between Rab proteins, RabGDIs, GEFs, and GAPs is essential for precise spatial and temporal control