Rab9dependent
Rab9-dependent refers to cellular trafficking pathways that require the small GTPase Rab9 for proper vesicle transport. Rab9 is a member of the Rab family of cytosolic GTPases and is primarily associated with late endosomes and the trans-Golgi network (TGN). In the Rab9-dependent retrograde pathway, cargo is retrieved from late endosomes back to the TGN, enabling recycling of receptors such as the mannose-6-phosphate receptor (MPR) and ensuring efficient delivery of lysosomal hydrolases to lysosomes.
Mechanistically, Rab9 cycles between an active GTP-bound state and an inactive GDP-bound state, a cycle regulated
Significance and regulation of Rab9-dependent transport are tied to lysosome biogenesis and intracellular sorting of lysosomal