Rab7iga
Rab7iga is a small GTPase proposed to belong to the Rab family of membrane trafficking regulators. The name reflects its putative interaction with Rab7 and its involvement in late endosome and lysosome pathways. In the current literature, Rab7iga has been described in a limited number of studies and is not yet widely characterized.
Molecularly, Rab7iga is predicted to adopt the conserved Rab fold, featuring a GTP-binding domain and switch
Functionally, Rab7iga is proposed to cycle between GDP- and GTP-bound forms, with the GTP-bound form promoting
Regulation and interactions are hypothesized to involve dedicated GEFs that accelerate nucleotide exchange and GAPs that
Research on Rab7iga remains exploratory. In cell models, perturbation of Rab7iga activity has been reported to