RNF20

RNF20, also known as RING finger protein 20, is a ubiquitin ligase enzyme. It plays a crucial role in cellular processes, particularly in chromatin regulation and gene expression. RNF20 is a component of the H2B ubiquitination complex, which is responsible for attaching ubiquitin molecules to histone H2B. This ubiquitination is a key post-translational modification that affects the structure of chromatin, making it more accessible for transcription factors and other regulatory proteins.

The activity of RNF20 is essential for the proper functioning of many cellular pathways. It has been implicated in DNA damage repair, cell cycle progression, and the maintenance of genomic stability. Dysregulation of RNF20 has been linked to various diseases, including cancer. In many types of cancer, RNF20 expression is found to be decreased, which can lead to aberrant gene expression and contribute to tumor development and progression. Research into RNF20 continues to shed light on its multifaceted roles in health and disease.