R4hydroxyglutarate

R4hydroxyglutarate, also known as R-2-hydroxyglutarate or (R)-2-hydroxyglutarate, is a chiral molecule. It is one of the stereoisomers of 2-hydroxyglutarate. The other stereoisomer is S4hydroxyglutarate. R4hydroxyglutarate is an alpha-hydroxy acid and a dicarboxylic acid.

In biological systems, R4hydroxyglutarate plays a role in intermediary metabolism. It is a product of the enzyme D-2-hydroxyglutarate dehydrogenase, which is involved in the conversion of alpha-ketoglutarate. Elevated levels of R4hydroxyglutarate are sometimes associated with certain metabolic disorders.

The chemical formula for R4hydroxyglutarate is C5H8O5. It is an endogenous metabolite, meaning it is produced within the body. Its presence and levels can be measured using various analytical techniques, such as mass spectrometry. While S4hydroxyglutarate is a more common metabolite in certain pathways, R4hydroxyglutarate has gained attention due to its association with specific pathological conditions. Research into the metabolic pathways involving R4hydroxyglutarate continues to be an area of scientific interest.