R2hydroxyglutarate

R2hydroxyglutarate, also known as R-2-hydroxyglutarate or R-2-HG, is a chiral molecule. It is an isomer of 2-hydroxyglutarate, with the R configuration at the chiral center. R2hydroxyglutarate is a metabolite produced by several biological pathways, including the Krebs cycle and amino acid metabolism. It can be formed from the reduction of alpha-ketoglutarate by specific enzymes. In certain physiological and pathological conditions, R2hydroxyglutarate levels can be elevated. It has been investigated for its role in cellular signaling and its potential as a biomarker. The presence and concentration of R2hydroxyglutarate can be influenced by factors such as diet and metabolic state. Its biochemical properties and interactions with cellular components are subjects of ongoing research.