Questran

Questran is a brand-name medication containing cholestyramine, a bile acid sequestrant used to lower elevated LDL cholesterol and to treat certain digestive symptoms. It is an anion-exchange resin that binds bile acids in the intestine, forming insoluble complexes that are excreted in the feces. By interrupting the enterohepatic circulation of bile acids, the liver converts more cholesterol into bile acids, which reduces circulating LDL cholesterol.

Indications include reduction of elevated LDL cholesterol as an adjunct to diet in primary hyperlipidemia, relief of intractable pruritus in partial biliary obstruction, and treatment of diarrhea due to bile acid malabsorption, such as that associated with ileal disease or resection.

Administration and dosing considerations: Questran is usually supplied as a powder that is mixed with water, juice, or other liquid and taken with meals. It should be swallowed promptly after preparation. To avoid interactions, other medications should be taken at least 1 hour before or 4 hours after Questran.

Side effects and monitoring: Common adverse effects are gastrointestinal and include constipation, bloating, gas, and upset stomach. Some people notice a taste alteration or unpleasant aftertaste. Long-term use may reduce absorption of fat-soluble vitamins (A, D, E, K) and certain other drugs; monitoring for deficiencies or interactions is advised. Patients should inform their prescriber of all medications to avoid interactions.

Contraindications and cautions: Do not use in complete bowel obstruction or known hypersensitivity to cholestyramine. Use in pregnancy or lactation should be discussed with a clinician, weighing potential benefits and risks. Regular follow-up is recommended to assess lipid levels and any adverse effects.