Printes

Printes refers to a family of protein complexes found in eukaryotic cells. These complexes play a crucial role in gene expression regulation, specifically in the process of messenger RNA (mRNA) export from the nucleus to the cytoplasm. The core function of printes is to facilitate the transport of mature mRNA molecules through the nuclear pore complexes.

The printes family is characterized by its modular structure, consisting of distinct subunits that assemble into functional units. A key component of printes is the protein called Gle1, which is essential for the binding of mRNA to the transport machinery. Other proteins, such as the DEAD-box RNA helicase Dbp5, are also integral to the printes complex and are involved in the remodeling of mRNA and the release of the transcript from the nuclear pore.

The activity of printes is tightly regulated, ensuring that only properly processed and mature mRNAs are exported. This process is vital for the proper functioning of the cell, as it allows the genetic information encoded in DNA to be translated into proteins in the cytoplasm. Dysregulation or mutations in printes components have been linked to various cellular defects and diseases, highlighting their importance in maintaining cellular homeostasis. Research into printes continues to uncover new insights into the complexities of nuclear export and gene regulation.