Plateletadhesion
Platelet adhesion is the process by which circulating platelets first attach to sites of vascular injury, anchoring to the subendothelial matrix and to exposed collagen and other proteins. This initial adhesion precedes platelet activation and aggregation, and is essential for formation of the primary hemostatic plug.
Mechanisms involve several receptor–ligand interactions. In the high-shear environment of arteries, platelet tethering is mediated mainly
Platelet adhesion leads to activation and release of mediators that recruit additional platelets and amplify the
Clinical relevance is related to defects in adhesion pathways. Von Willebrand disease reduces vWF-mediated adhesion; Bernard-Soulier