PhredScoreVerteilung

Phred Score Verteilung is a statistical distribution used in bioinformatics to describe the quality scores of sequencing reads. It is a probability distribution that models the frequency of occurrence of different quality scores, typically in the range of 0 to 41.

The Phred Score Verteilung is based on the assumption that sequencing errors are randomly distributed and independent of each other. The distribution is characterized by its parameters, which are determined by the sequencing technology and the base calling algorithm used. The most common form of the distribution is the Poisson distribution, but other distributions such as the normal distribution or the binomial distribution can also be used.

The quality scores assigned to sequencing reads are inversely related to the probability of sequence errors. Therefore, the Phred Score Verteilung can be used to estimate the error rates of sequencing reads and to call high-quality variants. The distribution can also be used to identify sequencing errors, such as insertions, deletions, and substitutions.

Phred Score Verteilung has become a widely used concept in bioinformatics and genomics. It is an essential tool for analyzing and interpreting high-throughput sequencing data. Due to its high accuracy and flexibility, the distribution has been integrated into many popular bioinformatics tools and pipelines. The distribution was first introduced in the early 1990s by Phil Green, a bioinformatics pioneer, and has since become a standard in the field.