Pfk
Pfk, most commonly referring to phosphofructokinase (PFK), is a central enzyme in glycolysis. It catalyzes the ATP-dependent phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate, a committed step that regulates glycolytic flux and energy production in cells.
In vertebrates, the primary catalytic activity comes from PFK-1, which forms a tetramer assembled from subunits
In bacteria and some other organisms, distinct pfk genes, such as pfkA and pfkB, encode different phosphofructokinases
Clinical and research relevance: hereditary deficiency of PFK-1 causes Tarui disease (glycogen storage disease type VII),
Notes: While Pfk most often denotes phosphofructokinase, the acronym can have other context-dependent meanings in different