Peräpuhenytteiden

Peräpuhenytteiden, also known as suppositories, are solid dosage forms intended for insertion into a body orifice where they melt, dissolve, or disperse, releasing their active ingredients. They are commonly used for rectal, vaginal, or urethral administration. The melting point of the base material is typically designed to be just above body temperature, ensuring release of the medication in situ.

Rectal suppositories are often used to treat local conditions such as hemorrhoids or constipation, or to administer systemic medications when oral administration is not feasible due to nausea, vomiting, or pre-operative conditions. Vaginal suppositories, or pessaries, are used for local gynecological treatments like infections or hormone replacement therapy. Urethral suppositories are less common but can be used for conditions affecting the urethra.

The base of a suppository is crucial for its performance. Common bases include fatty bases like cocoa butter, which melts at body temperature, and water-soluble bases like polyethylene glycols, which dissolve in body fluids. Excipients such as emollients, binders, and disintegrants may also be included to improve stability, texture, and drug release characteristics. The manufacturing process typically involves melting the base, incorporating the active ingredient, and molding the mixture into the desired shape. Peräpuhenytteiden offer an alternative route of administration for various therapeutic purposes.