Pegivirus

Pegivirus is a genus of viruses in the order Picornavirales, family Marnaviridae. These are single-stranded, positive-sense RNA viruses. The name "Pegivirus" is derived from "Picornavirus-like" and "hepatitis G virus," reflecting their initial association with the hepatitis G virus, which was later reclassified as a pegivirus.

Pegiviruses are known to infect a variety of mammalian hosts, including humans, bats, rodents, and non-human primates. In humans, pegiviruses, particularly human pegivirus (HPgV), were initially discovered as a potential cause of non-A to G hepatitis, though their pathogenic role is now considered minor or non-existent in immunocompetent individuals. They are often found as persistent, asymptomatic infections.

Transmission routes for pegiviruses are not fully understood but are suspected to include parenteral (e.g., bloodborne) and possibly fecal-oral routes. They have been detected in blood, saliva, and other bodily fluids. While typically not causing overt disease, pegiviruses have been investigated for potential roles in modulating immune responses and influencing the course of other infections, such as HIV. Research into pegiviruses continues to explore their biology, host interactions, and potential implications for health.