Pdcatalyzed
Pd-catalyzed refers to chemical reactions that are accelerated by palladium catalysts, typically enabling the formation of carbon–carbon bonds and, in some cases, carbon–heteroatom bonds under mild conditions. The central idea is a catalytic cycle in which palladium alternates oxidation states to facilitate bond construction and catalyst turnover. A hallmark of many Pd-catalyzed processes is cross-coupling, where two fragments are joined by a new bond through oxidative addition of a substrate to Pd, transmetalation with a nucleophilic partner, and reductive elimination to release the product and regenerate Pd(0).
The most prominent examples are palladium-catalyzed cross-couplings. Suzuki–Miyaura coupling links aryl or vinyl halides with boronic
Catalysts typically feature palladium precursors such as Pd(PPh3)4 or PdCl2-based complexes paired with ligands (phosphines, N-heterocyclic
Historical note: palladium-catalyzed cross-coupling earned the 2010 Nobel Prize in Chemistry for Heck, Negishi, and Suzuki.