Pancreasin

Pancreasin is a term sometimes used to refer to the collective enzymatic content of pancreatic juice, particularly in the context of therapeutic preparations derived from animal pancreases. These preparations are primarily used as digestive aids. The key enzymes found in pancreatin include amylase, lipase, and proteases such as trypsin and chymotrypsin. Amylase breaks down carbohydrates, lipase digests fats, and proteases break down proteins.

Historically, pancreatin was extracted from the pancreas of pigs and cattle. These extracts were then purified and formulated into tablets or capsules. The primary indication for pancreatin therapy is exocrine pancreatic insufficiency, a condition where the pancreas does not produce or release enough digestive enzymes. This can be caused by various diseases, including chronic pancreatitis, cystic fibrosis, and pancreatic cancer. Without adequate enzymes, individuals may experience malabsorption, leading to symptoms like steatorrhea (fatty stools), weight loss, and nutritional deficiencies.

When administered orally, pancreatin supplements help to supplement the body's own insufficient digestive enzymes, allowing for more effective digestion and absorption of nutrients from food. The dosage and specific enzyme composition of pancreatin preparations can vary, and they are typically prescribed by a healthcare professional. While effective, potential side effects can include gastrointestinal upset. Modern enzyme replacement therapies often use more refined and standardized preparations, but the term pancreatin remains associated with these pancreatic enzyme supplements.