PUVAterápia

PUVAterapia is a photochemotherapy treatment used to manage certain skin conditions. The name is derived from its two primary components: Psoralen and Ultraviolet A (UVA) light. Psoralen is a photosensitizing agent, meaning it makes the skin more sensitive to light. It can be administered orally, in a bath, or topically. UVA light is then applied to the treated areas of the skin.

The mechanism of action involves psoralen being absorbed by the skin cells and then activated by UVA light. This activation triggers a photochemical reaction that interferes with the rapid cell division characteristic of various dermatological conditions. Specifically, it inhibits DNA replication and cell proliferation, thereby reducing inflammation and the growth of affected skin.

PUVAterapia is primarily indicated for moderate to severe cases of psoriasis that have not responded well to topical treatments. It is also used for treating atopic dermatitis (eczema), vitiligo, and certain types of cutaneous T-cell lymphoma. The treatment sessions are typically administered a few times per week in a controlled medical setting, with the duration and intensity of UVA exposure gradually adjusted based on the patient's response and skin type.

While effective, PUVAterapia carries potential side effects. Short-term side effects can include nausea (if psoralen is taken orally), itching, redness, and a burning sensation similar to sunburn. Long-term risks, particularly with extensive or prolonged treatment, may include premature skin aging and an increased risk of developing skin cancers, such as squamous cell carcinoma and melanoma. Therefore, careful monitoring by a dermatologist is essential during and after PUVAterapia.