PTGER4

PTGER4, also known as the prostaglandin E receptor 4, is a protein-coding gene. It encodes a G protein-coupled receptor that is a key component of the prostaglandin signaling pathway. Prostaglandins are lipid compounds that play a crucial role in various physiological processes, including inflammation, pain, fever, and reproduction. PTGER4 specifically binds to prostaglandin E2 (PGE2), a potent mediator of these processes.

The PTGER4 receptor is widely expressed in numerous tissues throughout the body, including the heart, lungs, kidneys, and brain. Its diverse expression pattern reflects its involvement in a broad range of biological functions. In the cardiovascular system, PTGER4 is implicated in regulating blood pressure and vascular tone. In the kidneys, it plays a role in salt and water homeostasis. Furthermore, PTGER4 is involved in immune responses and has been linked to inflammatory conditions.

Dysregulation of PTGER4 signaling has been associated with various diseases. For instance, alterations in its expression or function can contribute to the development of hypertension, kidney disease, and inflammatory disorders. Research into PTGER4 continues to explore its precise roles in health and disease, with a focus on its potential as a therapeutic target for conditions where prostaglandin E2 signaling is implicated. Understanding the intricate mechanisms of PTGER4 activation and its downstream effects is crucial for developing targeted interventions.