PSD95DlgZO1

PSD95DlgZO1 refers to a protein complex formed by the interaction of PSD95 (Postsynaptic density protein 95) andDlg (Discs large) family proteins, including ZO1 (Zonula occludens 1). PSD95 is a crucial scaffolding protein found in the postsynaptic density of excitatory synapses in the central nervous system. It plays a vital role in organizing neurotransmitter receptors, ion channels, and signaling molecules at the synapse. Dlg proteins, such as ZO1, are also known as MAGUKs (Membrane-associated guanylate kinase) and are involved in cell adhesion and signaling.

The interaction between PSD95 and Dlg proteins, particularly ZO1, is significant in assembling and stabilizing multiprotein complexes at cell junctions. In neurons, PSD95 binds to Dlg proteins through specific protein-protein interaction domains, such as the PDZ domains of PSD95 and specific motifs on Dlg. This association helps to anchor and cluster various synaptic proteins, contributing to synaptic structure and function. ZO1, in particular, is known for its role in tight junctions in epithelial cells, but its interaction with PSD95 highlights a shared molecular mechanism for organizing protein complexes at different types of cell-cell interfaces. The PSD95DlgZO1 complex is believed to be involved in regulating synaptic plasticity, learning, and memory. Dysregulation of this complex has been implicated in neurological disorders.