PMLRARAdriven
PMLRARAdriven refers to a specific type of molecular fusion protein that plays a significant role in certain hematological malignancies, particularly acute promyelocytic leukemia (APL). This fusion protein arises from a chromosomal translocation, most commonly t(15;17), which fuses the Promyelocytic Leukemia (PML) gene with the Retinoic Acid Receptor Alpha (RARα) gene. The resulting PMLRARα protein is a transcription factor that disrupts normal cellular differentiation pathways.
In healthy cells, RARα binds to retinoic acid and regulates gene expression involved in cell development. However,
The discovery of the PMLRARα fusion protein was a major breakthrough in understanding APL pathogenesis. It