PITP
PITP stands for phosphatidylinositol transfer protein, a family of small cytosolic proteins that shuttle phosphatidylinositol (PI) and phosphatidylinositol 4-phosphate (PI4P) between membrane compartments, thereby regulating phosphoinositide signaling and membrane trafficking. In humans, the best characterized members are PITP alpha (PITPNA) and PITP beta (PITPNB). These proteins carry out lipid transfer by binding PI and PI4P in a conserved lipid-binding pocket, enabling exchange of lipids between donor and acceptor membranes at sites such as the endoplasmic reticulum and Golgi apparatus, as well as at membrane contact sites.
PITP proteins support various cellular processes, including vesicle formation, endocytosis, and receptor signaling, by maintaining appropriate
Genetic and biochemical studies have linked PITP dysfunction or altered expression to disruptions in signaling pathways
In other contexts, the acronym PITP is used for terms or programs unrelated to this protein family;