PCNAs
PCNA is a protein that functions as a homotrimer and is found in the nucleus of eukaryotic cells. It is also known as cyclin-dependent cell proliferation nuclear antigen. PCNA is a highly conserved protein, meaning its structure is similar across different species. Its primary role is as a processivity factor for DNA polymerase delta and epsilon. In simpler terms, PCNA helps these enzymes to synthesize DNA more efficiently and for longer stretches. This is crucial for DNA replication, a fundamental process for cell division.
Beyond its role in replication, PCNA is also involved in DNA repair pathways. It acts as a