PBX1PBX4

PBX1PBX4 refers to the gene that encodes the pre-B-cell leukemia transcription factor 1 and pre-B-cell leukemia transcription factor 4 proteins. These proteins are members of the PBX homeodomain protein family, which are important regulators of gene expression. PBX1 and PBX4 are known to interact with other transcription factors, such as HOX proteins and MEIS proteins, to control the development and differentiation of various cell types. They play roles in embryonic development, particularly in the formation of limbs, central nervous system, and hematopoietic system. Dysregulation of PBX1PBX4 has been implicated in certain types of cancer, where they can contribute to uncontrolled cell growth and proliferation. Research continues to explore the precise mechanisms by which PBX1 and PBX4 function and their involvement in both normal development and disease states. Understanding these proteins is crucial for developing targeted therapies for conditions associated with their aberrant activity.