PAR3PAR6aPKCkomplekset

The PAR3PAR6aPKC complex is a crucial protein assembly involved in establishing cell polarity. This complex plays a significant role in cell division and the formation of epithelial tissues. Its primary function is to regulate the asymmetric distribution of proteins within a cell, which is essential for creating distinct apical and basolateral domains.

The core components of this complex include PAR3 (Partition defective 3), PAR6 (Partition defective 6), and atypical protein kinase C (aPKC). These proteins interact in a specific manner to form a stable scaffold. PAR3 acts as an adaptor protein, binding to PAR6 and other downstream effectors. PAR6, in turn, recruits aPKC, a kinase that phosphorylates various target proteins. This phosphorylation can alter the localization and activity of these targets, thereby influencing cytoskeletal organization and membrane trafficking.

The precise spatial regulation of the PAR3PAR6aPKC complex is critical. Its recruitment to specific cellular regions, often at the cell cortex, initiates downstream signaling pathways that define cell polarity. Disruptions in the function or localization of this complex can lead to developmental defects and diseases, highlighting its fundamental importance in cellular organization and function.