OrbitrapQQQ

OrbitrapQQQ is a type of mass spectrometer used in proteomics and metabolomics for the identification and quantification of biomolecules. It combines the Orbitrap mass analyzer with a triple quadrupole (QQQ) mass analyzer, providing high-resolution and high-accuracy mass measurements along with the ability to perform targeted and untargeted analyses.

The Orbitrap mass analyzer is a Fourier transform ion cyclotron resonance (FT-ICR) mass analyzer that provides high-resolution and high-accuracy mass measurements. It works by trapping ions in a magnetic field and measuring their cyclotron frequency, which is directly proportional to their mass-to-charge ratio. The Orbitrap mass analyzer is known for its high mass accuracy and resolution, making it ideal for the identification of biomolecules.

The triple quadrupole mass analyzer consists of three quadrupole mass filters in series. The first quadrupole (Q1) selects the precursor ion, the second quadrupole (Q2) fragments the precursor ion, and the third quadrupole (Q3) selects the fragment ion. The triple quadrupole mass analyzer is known for its high selectivity and sensitivity, making it ideal for targeted analyses.

The OrbitrapQQQ mass spectrometer combines the high-resolution and high-accuracy mass measurements of the Orbitrap mass analyzer with the high selectivity and sensitivity of the triple quadrupole mass analyzer. This combination allows for the identification and quantification of biomolecules with high accuracy and sensitivity. The OrbitrapQQQ mass spectrometer is widely used in proteomics and metabolomics for the identification and quantification of biomolecules in complex biological samples.