Nnitrosodiethanolamine

N-nitrosodiethanolamine, often abbreviated as NDELA, is a chemical compound that belongs to the nitrosamine family. It is formed through the reaction of diethanolamine with nitrosating agents, which can be naturally occurring in the environment or present in various products. NDELA is not intentionally manufactured for use as an ingredient but can arise as a contaminant or byproduct.

This compound has been detected in a range of consumer products, including cosmetics, detergents, and metalworking fluids. Its presence is often a result of the formulation process where ingredients containing diethanolamine are exposed to nitrites or other nitrogen oxides. Regulatory bodies in many countries monitor the levels of NDELA in consumer goods due to concerns about its potential health effects.

Studies have indicated that NDELA is a probable human carcinogen. Animal studies have shown it to be associated with an increased risk of certain cancers. Consequently, its presence in products that come into contact with skin or are used in ways that could lead to ingestion or inhalation is a subject of ongoing scrutiny and regulation. Manufacturers are often required to limit or eliminate NDELA from their formulations. The chemical structure of NDELA consists of a nitrosamine group (-N=O) attached to two hydroxyethyl groups (-CH2CH2OH). It is a viscous liquid at room temperature and is soluble in water and alcohol.