Nevirapiini

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used in the treatment of human immunodeficiency virus type 1 (HIV-1) infection. It works by blocking the action of reverse transcriptase, an enzyme that HIV needs to make copies of itself. By inhibiting this enzyme, nevirapine helps to reduce the amount of HIV in the body, which can improve immune function and slow the progression of the disease.

Nevirapine is typically taken orally, usually as a single daily dose. It is often used in combination with other antiretroviral medications as part of a comprehensive treatment regimen for HIV. The combination of drugs is important to prevent the development of drug resistance.

Common side effects of nevirapine include rash, nausea, vomiting, diarrhea, and elevated liver enzymes. Serious side effects, though less common, can include severe skin reactions such as Stevens-Johnson syndrome and toxic epidermal necrolysis, and liver damage. Regular monitoring of liver function and skin reactions is recommended during treatment.

Nevirapine is also used in prevention of mother-to-child transmission of HIV. A single dose given to the mother during labor and to the newborn shortly after birth can significantly reduce the risk of transmission.

The development of drug resistance is a concern with nevirapine, as with all antiretroviral drugs. Adherence to the prescribed treatment regimen is crucial to maintain viral suppression and prevent resistance. Nevirapine is manufactured by Boehringer Ingelheim.