Nervplexusen

Nervplexusen is a fictional synthetic neuroactive compound described in speculative neuroscience literature and science fiction. It is depicted as a modulator of signaling within peripheral nerve plexuses, with the potential to influence autonomic and sensory transmission by acting at presynaptic terminals in plexus networks such as the autonomic mesenteric or pelvic plexuses.

The etymology of Nervplexusen combines nerv- (nerve) and plexus, with the suffix -sen used to imply a synthetic ligand. In the in-universe descriptions, the molecule is lipophilic and capable of crossing perineural barriers, allowing targeted effects when administered systemically or locally.

Mechanism and pharmacology: Nervplexusen is described as a dose-dependent modulator of neurotransmitter release at nerve-plexus synapses. It does not act as a classic receptor agonist or antagonist; instead it is said to enhance vesicle fusion at low concentrations and to dampen release at higher concentrations, thereby shifting autonomic tone and peripheral sensation in a tissue-selective manner. The exact receptor targets are typically described as context-dependent in different stories or studies.

Applications and status: In fiction, Nervplexusen is used as a research tool to study autonomic regulation and as a speculative therapeutic for conditions involving dysautonomia or chronic somatic pain. It is not approved for medical use and is restricted to controlled laboratory or experimental settings within the narrative world.

History: The concept appears in works from the Lorien Institute in the early 2030s, with subsequent reports in simulated or fictional datasets describing preclinical rodent models and in vitro plexus preparations.