Nanoporenbasierte

Nanoporenbasierte refers to technologies and applications that utilize nanopores, which are nanoscale holes or channels. These pores are typically between 1 and 100 nanometers in diameter and can be fabricated from various materials, including solid-state materials like silicon nitride or silicon, and biological materials like protein channels. The fundamental principle behind nanopore-based technologies is the ability to detect and analyze individual molecules as they pass through or interact with a nanopore.

When a molecule traverses a nanopore, it causes a temporary disruption in the electrical current flowing through the pore. This change in current, known as a blockade, is unique to the size, shape, and chemical properties of the molecule. By measuring and analyzing these current fluctuations, researchers can identify, quantify, and even sequence molecules with high sensitivity and resolution.

A prominent application of nanopore technology is DNA and RNA sequencing. As a strand of nucleic acid passes through a nanopore, the sequence of bases can be inferred from the characteristic current blockade patterns. This method offers the potential for rapid, portable, and cost-effective sequencing, opening up new possibilities in genomics, diagnostics, and personalized medicine. Beyond nucleic acids, nanopore-based sensing is also being explored for detecting proteins, small molecules, and even viruses, making it a versatile platform for a wide range of scientific and technological advancements.