NTerminirelated

N-Terminal Related, also known as N-terminal extension (NTE), is a type of protein modification that involves the addition of a sequence of amino acids to the N-terminal end of a protein. This modification can occur through various post-translational modifications (PTMs) such as ubiquitination, acetylation, or phosporylation.

N-Terminal Related modifications can affect protein function, localization, and stability, often leading to changes in protein-protein interactions or enzymatic activity. Some N-Terminal Related modifications can also serve as a regulatory mechanism, controlling protein activity or function in response to specific cellular signals or environmental cues.

Research on N-Terminal Related modifications has been expanding in recent years, due to their relevance in various biological processes, including signal transduction, cellular metabolism, and disease pathogenesis. Specific modifications, such as ubiquitination of the N-terminus, have been implicated in the regulation of protein degradation, highlighting the importance of this modification in maintaining proteostasis.

Several methods have been developed to study N-Terminal Related modifications, including mass spectrometry, Western blotting, and enzyme-linked immunosorbent assays (ELISAs). Characterization of N-Terminal Related modifications has been challenging due to the reversibility of some modifications, making it difficult to determine the original sequence of the protein.

Overall, N-Terminal Related modifications play a crucial role in regulating protein function and cellular processes, and further research is needed to understand the complexity of these modifications and their implications in both physiology and disease.