NCOA3SRC3

ncoa3src3 refers to a specific domain or variant of the nuclear receptor coactivator 3 protein, also known as src3 or aib1. this protein is a member of the p160/src family of coactivators that play crucial roles in nuclear receptor signaling pathways. ncoa3src3 contains specific functional domains that enable it to interact with various transcription factors and chromatin remodeling complexes. the protein is involved in regulating gene expression by facilitating the assembly of large multiprotein complexes at target gene promoters. ncoa3src3 has been extensively studied for its role in hormone-dependent cancers, particularly breast cancer, where it often shows amplified expression. the protein contains multiple activation domains, including three conserved lxxll motifs that mediate interactions with nuclear hormone receptors. research suggests that ncoa3src3 may serve as a therapeutic target in certain cancers due to its overexpression in malignant tissues and its involvement in cell proliferation and survival pathways. the specific designation ncoa3src3 may refer to particular isoforms or post-translationally modified forms of this important coactivator protein.